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Different groups of proteins shown in different colors combine and attach to a broken strand of DNA.

Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair. Decoding NER’s sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.

Three egg-shaped orbs of varying opacity are shown on a dark blue background, increasing transparency revealing they are filled with smaller round balls of red and blue. Arrows indicate counterclockwise rotation of the orbs, and green squiggles imply motion of the smaller balls.

Using the Frontier supercomputer at ORNL, researchers have developed a new technique that predicts nuclear properties in record detail. The study revealed how the structure of a nucleus relates to the force that holds it together. This understanding could advance efforts in quantum physics and across a variety of sectors, from to energy production to national security.

Six images fanned out across the right side of the page with the first page showcasing the report cover. To the right hand side is a green oak leaf.

A workshop led by scientists at ORNL sketched a road map toward a longtime goal: development of autonomous, or self-driving, next-generation research laboratories. 

Hugh O'Neil, director or ORNL's Center for Structural Molecular Biology is sitting in the lab on a stool, hand on desk with glasses on. There are lab related items blurred in the foreground.

Hugh O’Neill’s lifelong fascination with the complexities of the natural world drives his research at ORNL, where he’s using powerful neutron beams to dive deep into the microscopic realm of biological materials and unlock secrets for better production of domestic biofuels and bioproducts.

ORNL researcher Melissa Cregger is standing outside smiling for a photo. Woman is wearing blue and white polka dot shirt with a purple cardigan.

Melissa Cregger of the Department of Energy’s Oak Ridge National Laboratory has received the Presidential Early Career Award for Science and Engineers, or PECASE, the highest honor bestowed by the U.S. government on outstanding early-career scientists and engineers. 

Procter & Gamble scientists used ORNL’s Summit supercomputer to create a digital model of the corneal epithelium, the primary outer layer of cells covering the human eye, and test that model against a series of cleaning compounds in search of a gentler, more environmentally sustainable formula.

P&G is using simulations on the ORNL Summit supercomputer to study how surfactants in cleaners cause eye irritation. By modeling the corneal epithelium, P&G aims to develop safer, concentrated cleaning products that meet performance and safety standards while supporting sustainability goals.

Picture shows magnetic domains in uranium with a blue and orange organic shapes, similar to lava flowing through water, but in graphic form

The US focuses on nuclear nonproliferation, and ORNL plays a key role in this mission. The lab conducts advanced research in uranium science, materials analysis and nuclear forensics to detect illicit nuclear activities. Using cutting-edge tools and operational systems, ORNL supports global efforts to reduce nuclear threats by uncovering the history of nuclear materials and providing solutions for uranium removal. 

ORNL computing staff members Hector Suarez (middle) and William Castillo (right) talk HPC at the Tapia Conference career fair in San Diego, California. Credit: ORNL, U.S. Dept of Energy

The National Center for Computational Sciences, located at the Department of Energy’s Oak Ridge National Laboratory, made a strong showing at computing conferences this fall. Staff from across the center participated in numerous workshops and invited speaking engagements.

Wide shot of the expo center, ground filled with people walking and a green, white and blue 3D circle sign above everyone in the center

The Department of Energy’s Oak Ridge National Laboratory had a major presence at this year’s International Conference for High Performance Computing, Networking, Storage, and Analysis (SC24). 

Four scientists are standing in a field next to a data-gathering tool robot

Scientists at the Department of Energy’s Oak Ridge National Laboratory recently demonstrated an autonomous robotic field monitoring, sampling and data-gathering system that could accelerate understanding of interactions among plants, soil and the environment.