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A deep look inside a cell membrane showing the production of materials from plant biomass, shown with shapes that consist of four green balls connected with a red ball on one end, dotted with smaller white balls on each surface.

Scientists at ORNL and the University of Cincinnati achieved a breakthrough in understanding the vulnerability of microbes to the butanol they produce during fermentation of plant biomass. The discovery could pave the way for more efficient production of domestic fuels, chemicals and materials.

A cargo ship to the left of the seaport with bright blue metal surrounding it

In collaboration with the U.S. Department of Homeland Security’s Science and Technology Directorate, researchers at ORNL are evaluating technology to detect compounds emitted by pathogens and pests in agricultural products at the nation’s border. 

Different groups of proteins shown in different colors combine and attach to a broken strand of DNA.

Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair. Decoding NER’s sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.

A male researcher is standing next to a poster board displayed on an easel to the right. The researcher is dressed in professional attire, and the poster board is positioned beside him, showing research or visual information.

Ryan Culler is the program manager at Oak Ridge National Laboratory, where he oversees the production of actinium-225, a promising treatment for cancer. Driven by a personal connection to cancer through his late brother, Culler is dedicated to advancing medical isotopes to help improve cancer care. 

Summit Supercomputer

Scientists conducted a groundbreaking study on the genetic data of over half a million U.S. veterans, using tools from the Oak Ridge National Laboratory to analyze 2,068 traits from the Million Veteran Program.

A graphical representation about a gene in a poplar tree. There is a close up of a tree to the right and the far left-top corner. There is a strand of DNA going down the middle of the image with an ant and two small circles showing the organisms inside the DNA

A team of scientists with two Department of Energy Bioenergy Research Centers — the Center for Bioenergy Innovation at Oak Ridge National Laboratory and the Center for Advanced Bioenergy and Bioproducts Innovation at the University of Illinois Urbana-Champaign — identified a gene in a poplar tree that enhances photosynthesis and can boost tree height by about 30% in the field and by as much as 200% in the greenhouse. 

microscopic ctherm biomass

Using a best-of-nature approach developed by researchers working with the Center for Bioenergy Innovation at the Department of Energy’s Oak Ridge National Laboratory and Dartmouth University, startup company Terragia Biofuel is targeting commercial biofuels production that relies on renewable plant waste and consumes less energy. The technology can help meet the demand for billions of gallons of clean liquid fuels needed to reduce emissions from airplanes, ships and long-haul trucks.

Graphic representation of ai model that identifies proteins

Researchers used the world’s fastest supercomputer, Frontier, to train an AI model that designs proteins, with applications in fields like vaccines, cancer treatments, and environmental bioremediation. The study earned a finalist nomination for the Gordon Bell Prize, recognizing Âé¶¹Ó°Òô in high-performance computing for science.

A photo of the inside of a cabinet for the Frontier supercomputer at ORNL

A team of researchers used the Frontier supercomputer and a new methodology for conducting a genome-wide association study to earn a finalist nomination for the Association for Computing Machinery’s 2024 Gordon Bell Prize for outstanding

Pictured is the IMAGINE instrument at the High Flux Isotope Reactor

Biochemist David Baker — just announced as a recipient of the Nobel Prize for Chemistry — turned to the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory for information he couldn’t get anywhere else. HFIR is the strongest reactor-based neutron source in the United States.