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The US focuses on nuclear nonproliferation, and ORNL plays a key role in this mission. The lab conducts advanced research in uranium science, materials analysis and nuclear forensics to detect illicit nuclear activities. Using cutting-edge tools and operational systems, ORNL supports global efforts to reduce nuclear threats by uncovering the history of nuclear materials and providing solutions for uranium removal. 

Researchers used the world’s fastest supercomputer, Frontier, to train an AI model that designs proteins, with applications in fields like vaccines, cancer treatments, and environmental bioremediation. The study earned a finalist nomination for the Gordon Bell Prize, recognizing Â鶹ӰÒô in high-performance computing for science.

A team of researchers used the Frontier supercomputer and a new methodology for conducting a genome-wide association study to earn a finalist nomination for the Association for Computing Machinery’s 2024 Gordon Bell Prize for outstanding

Biochemist David Baker — just announced as a recipient of the Nobel Prize for Chemistry — turned to the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory for information he couldn’t get anywhere else. HFIR is the strongest reactor-based neutron source in the United States.  

Scientists at ORNL used neutrons to end a decades-long debate about an enzyme cancer uses.

After retiring from Y-12, Scott Abston joined the Isotope Science and Engineering Directorate to support isotope production and work with his former manager. He now leads a team maintaining critical equipment for medical and space applications. Abston finds fulfillment in mentoring his team and is pleased with his decision to continue working.

Jeremiah Sewell leads a team at ORNL, working on xenon-129 production for lung imaging. Reflecting on his career, Sewell views each opportunity as a "door" he steps through, leveraging over 25 years of experience in nuclear power and centrifuge operations to advance the facility’s mission.

Brian Sanders is focused on impactful, multidisciplinary science at Oak Ridge National Laboratory, developing solutions for everything from improved imaging of plant-microbe interactions that influence ecosystem health to advancing new treatments for cancer and viral infections. 

Researchers set a new benchmark for future experiments making materials in space rather than for space. They discovered that many kinds of glass have similar atomic structure and arrangements and can successfully be made in space. Scientists from nine institutions in government, academia and industry participated in this 5-year study. 

The BIO-SANS instrument, located at Oak Ridge National Laboratory’s High Flux Isotope Reactor, is the latest neutron scattering instrument to be retrofitted with state-of-the-art robotics and custom software. The sophisticated upgrade quadruples the number of samples the instrument can measure automatically and significantly reduces the need for human assistance.